The Full form of MP is Mucopolysaccharidoses. MPs are a group of metabolic disorders caused by the malfunctioning or absence of lysosomal enzymes needed to break down molecules called Glycosaminoglycans. These long chains of sugar carbohydrates occur within the cells that help build bone, corneas, skin cartilage, tendons, and connective tissue. Glycosaminoglycans (formerly called Mucopolysaccharides) are also found in the fluids that lubricate joints. Individuals with MPs either do not produce enough of one of the eleven enzymes required to break down these sugar chains into simpler molecules, or they produce enzymes that do not work properly. Over time, these Glycosaminoglycans collect in the blood, cells, and connective tissues. The result is permanent, progressive cellular damage which affects appearance, physical abilities, system and organ functioning and, in most cases, mental development. The MPs are part of the lysosomal storage disease family, a group of more than 40 genetic disorders that result when the lysosome organelle in animal cells malfunctions. The lysosome can be thought of as the cell’s recycling center because it processes unwanted material into other substances via enzymes that the cell can utilize. Lysosomal disorders like Mucopolysaccharidosis are triggered when a particular enzyme exists in too small an amount or is missing altogether.
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